Back to Search
Start Over
Flow-Based Autocorrelation Studies for the Detection and Investigation of Single-Particle Surface-Enhanced Resonance Raman Spectroscopic Events.
- Source :
-
Analytical Chemistry . 2/15/2011, Vol. 83 Issue 4, p1418-1424. 7p. 5 Graphs. - Publication Year :
- 2011
-
Abstract
- We report on the characterization and detection of single metallic nanoparticles using a combination of con-elation spectroscopy and surface-enhanced resonance Raman spectroscopy (SERRS). Minimizing the number of independent characterization steps is critical to efficiently perform such an analysis. In this article, we improve upon conventional diffusion-limited approaches by implementing a flow-based system with high temporal resolution detection. The benefits of flow over diffusion measurements allow for a higher throughput of detected events resulting in shorter analysis times. The nanoparticles are sized using their rotational diffusion time calculated with a modified autocorrelation function. Experiments are performed using Au nanoparticles labeled with the reporter molecule malachite green isothiocyanate on a custom-built Raman spectrometer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00032700
- Volume :
- 83
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Analytical Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 59217932
- Full Text :
- https://doi.org/10.1021/ac102925h