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Thienopyrrole acetic acids as antagonists of the CRTH2 receptor
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Mar2011, Vol. 21 Issue 6, p1861-1864. 4p. - Publication Year :
- 2011
-
Abstract
- Abstract: The bioisosteric replacement of the indole core of CRTH2 antagonists using thienopyrroles was investigated, resulting in potent antagonists with good selectivity over DP1. Early ADME/PK assessment of this chemotype demonstrated bioavailability in mice. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 21
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 59195070
- Full Text :
- https://doi.org/10.1016/j.bmcl.2011.01.008