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Cytotoxic mechanisms may play a role in the local immune response in the central nervous system in neuroborreliosis
- Source :
-
Journal of Neuroimmunology . Mar2011, Vol. 232 Issue 1/2, p186-193. 8p. - Publication Year :
- 2011
-
Abstract
- Abstract: Aiming to investigate the role of cytotoxic mechanisms in neuroborreliosis (NB), the cytokines IL-2, IL-7, IL-10, IL-12p70, IL-15, GM-CSF and the Th17-cytokine IL-17 were analyzed in cerebrospinal fluid (CSF) and plasma from NB-patients. NB-patients showed increased levels in CSF compared to controls of all analyzed cytokines except IL-15 but not in plasma. Blood lymphocytes from three NB-patients showed functional cytotoxicity in response to autologous Borrelia-infected macrophages. The findings support a role for cytotoxic mechanisms in the local immune response in NB and in addition suggest an increase of IL-17. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01655728
- Volume :
- 232
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Journal of Neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 59169725
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2010.09.028