Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population

Abstract: Aims: The CIDEA gene is involved in energy metabolism and a non-synonymous single nucleotide polymorphism (SNP), V115F (G/T), is a risk factor for obesity in Swedish subjects and metabolic syndrome (MetS) in Japanese subjects. However, the risk allele was a G in Swedish subjects and a T in Japanese subjects. The present study investigated the association between this SNP and MetS in a Chinese population. Methods: Three hundred and fifty-one subjects evaluated at the Cardiac Clinic in Xuanwu Hospital for MetS risks were recruited. Anthropometric measurements, blood pressure, fasting blood glucose, and blood lipid levels were determined in addition to the polymorphism. Results: The proportion of subjects with MetS was significantly higher based on genotype, in the order: GG<GT<TT (p =0.003). In multiple logistic regression analysis, the odds ratios for MetS in the GT and TT genotypes, compared to the referent GG genotype, were 2.26 (p =0.003) and 2.89 (p =0.002), respectively. Similar trends were observed for the related phenotypes of central obesity (GT: OR=2.20, p =0.004; TT: OR=3.31, p =0.002) and dyslipidemia (GT: OR=1.73, p =0.047; TT: OR=2.10, p =0.03). Conclusions: The T allele of the CIDEA V115F SNP is a risk factor for MetS and its related phenotypes in a Chinese population. [Copyright &y& Elsevier]