Tratamiento de la vejiga hiperactiva. Estudio comparativo, experimental, aleatorizado de sulfato de atropina vs dimetilsulfóxido intravesical en 10 dosis intravesicales.

Background: Overactive bladder has a significant effect on quality of life, reflected in social isolation and depression. Urinary urgency is defined as the urgent need to urinate, a characteristic symptom of overactive bladder syndrome. Antimuscarinics are the first line of treatment for urgency-frequency, but are associated with adverse effects that limit their use. Objective: To compare the results of 2 treatments: intravesical atropine sulphate vs. dimethylsulfoxide (DMSO). Both treatments were effective in evaluation of nocturia, bladder capacity, frequency, urinary urgency and scale in quality of life in our population of patients with overactive bladder. Methods: An experimental, longitudinal, prospective, comparative, randomized study was conducted of 14 women with overactive bladder diagnosis confirmed by urodynamics study at the University Hospital Dr. Jose Eleuterio Gonzalez. These women were divided into 2 groups. In group 1, n = 7 were applied 10 doses of 6.0 mg intravesical atropine sulphate diluted in 20 mL saline. In group 2, n = 7 were applied 10 doses of intravesical DMSO 50% (25 mL to 100% diluted in 25 mL of saline solution). Main variables were recorded as urinary frequency, nocturia, urinary urgency, bladder capacity before and after treatment with urodynamics and were evaluated with the quality of life survey OAB-q before and after of treatment. Results: There was a significant (p = 0.002) in urinary frequency in both groups after 10 doses of treatment, and nocturia decreased in both groups after 10 doses bladder (p = 0.003). No statistically significant changes were found when comparing the results of urinary frequency and nocturia 30 days after completion of treatment is to be inferred that the changes were maintained over 30 days after treatment. There was an increase of 99 mL in bladder capacity in the patient group treated with atropine sulfate, proven by urodynamic studies, with reduced urinary urgency by 86% in the DMSO group showed an increase of 85 mL in bladder capacity proven by urodynamic studies, with reduced urinary urgency by 86%. The OAB-q survey to assess the quality of life at baseline and after 7 days of treatment was repeated this survey with an average score of 0 to 35 points in both groups with an average of 12 points in group 1 and half from 23.7 points in group 2 when comparing two means using the Student t test was obtained (p = 0.18) not significant. Conclusions: Through the results of this study we conclude that the hypothesis is accepted clinical improvement work in relation to nocturia, bladder capacity, urgency, urinary frequency and quality of life through the use of Atropine Sulfate these results are comparable and in some respects superior to the results obtained using dimethyl sulfoxide 50%. [ABSTRACT FROM AUTHOR]