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Very long-term remission induced by short-term rituximab monotherapy in a patient with heavily pretreated, chronic immune thrombocytopenic purpura.

Authors :
Clausen, Michael R.
Segel, Erik
Brandsborg, Margrethe
d'Amore, Francesco
Source :
European Journal of Haematology. Mar2011, Vol. 86 Issue 3, p256-259. 4p. 1 Black and White Photograph, 1 Chart.
Publication Year :
2011

Abstract

The management of patients with refractory immune thrombocytopenic purpura (ITP) may be difficult. We describe a rapid-onset very long-term remission (9 years) induced by short-term rituximab monotherapy in a 62-year-old man with treatment-refractory chronic ITP. Over a 30-year period from the original diagnosis to last follow-up, the patient needed renewed treatment twelve times within the first two decades and was subsequently brought in continuous complete remission for the last decade by a single course of rituximab. The effect of rituximab in ITP has previously been described. However, in chronic, treatment-refractory ITP occurring in elderly patients, remission rates tend to be low and of short duration. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09024441
Volume :
86
Issue :
3
Database :
Academic Search Index
Journal :
European Journal of Haematology
Publication Type :
Academic Journal
Accession number :
58467952
Full Text :
https://doi.org/10.1111/j.1600-0609.2010.01561.x