Back to Search Start Over

(−)-α-Bisabolol attenuates visceral nociception and inflammation in mice

Authors :
Leite, Gerlânia de O.
Leite, Laura H.I.
Sampaio, Renata de S.
Araruna, Mariana Késsia A.
de Menezes, Irwin Rose A.
da Costa, José Galberto M.
Campos, Adriana R.
Source :
Fitoterapia. Mar2011, Vol. 82 Issue 2, p208-211. 4p.
Publication Year :
2011

Abstract

Abstract: The study examined the antiinflammatory and antinociceptive effects of the sesquiterpene (−)-α-bisabolol (BISA). The antiinflammatory effect was evaluated on acute models of dermatitis induced by Croton oil, arachidonic acid, phenol and capsaicin, respectively, in mouse ear. BISA inhibited the dermatitis induced by all noxious agents, except capsaicin. BISA was assessed in two established mouse models of visceral nociception. Mice were pretreated orally with BISA, and the pain-related behavioral responses to intraperitoneal cyclophosphamide or to intracolonic mustard oil were analyzed. BISA showed a dose-unrelated significant antinociception. Collectively, the results suggest that BISA may be an topical antiinflammatory and visceral antinociceptive agent. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0367326X
Volume :
82
Issue :
2
Database :
Academic Search Index
Journal :
Fitoterapia
Publication Type :
Academic Journal
Accession number :
57515445
Full Text :
https://doi.org/10.1016/j.fitote.2010.09.012