Three New Eudesmanolactones (=Eudesmanolides) from Camchaya loloana.

Three new eudesmanolactones (=eudesmanolides), loloanolide A (), loloanolide B (), and 1- O-acetylloloanolide B (), together with five known compounds, were isolated from the CHCl extract of the aerial parts of Camchaya loloana. Their structures were elucidated on the basis of spectroscopic analysis. This type of eudesmanolactones bearing a 2-(hydroxymethyl)acryloyloxy group at C(8) was discovered for the first time. Compounds - exhibited cytotoxicity against the HepG2 cell line, with GI values of 22.9, 18.1, and 12.8 nmol/ml, respectively. [ABSTRACT FROM AUTHOR]