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Meeting-in-the-middle using metabolic profiling -- a strategy for the identification of intermediate biomarkers in cohort studies.
- Source :
-
Biomarkers . Feb2011, Vol. 16 Issue 1, p83-88. 6p. 1 Diagram, 1 Chart, 1 Graph. - Publication Year :
- 2011
-
Abstract
- Background: Predictive disease risk biomarkers that can be linked to exposure have proved difficult to identify in case-control studies. Methods: Parallel statistical analysis of the correlation between 1H NMR profiles from plasma samples collected before disease onset (EPIC cohort), versus exposure to dietary compounds, and follow-up disease endpoints (colon and breast cancer) was performed. Results: Metabonomic signatures associated with colon cancer and dietary fiber intake (a protective factor according to epidemiological studies) were identified. Conclusion: This implementation of the novel '' meet-in-the-middle'' analytical strategy indicates how case-control studies nested in prospectively collected cohorts may reveal intermediate biomarkers linking exposure and disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1354750X
- Volume :
- 16
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 57439746
- Full Text :
- https://doi.org/10.3109/1354750X.2010.533285