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New bilayer-coated microbead system for controlled release of 5-aminosalicylic acid.
- Source :
-
Polymer Bulletin . Feb2011, Vol. 66 Issue 3, p433-443. 11p. - Publication Year :
- 2011
-
Abstract
- new bilayer-coated microbeads for oral delivery of 5-aminosalicylic acid (5-ASA) were prepared from naturally occurring polysaccharides via emulsification method. 5-ASA was successfully encapsulated in chitosan-λ-carrageenan-coated alginate microbeads. The morphology and sizes of microparticles were studied using optical microscopy and dynamic light scattering. Drug release profiles were followed using high-performance liquid chromatography (HPLC) with spectrophotometric detection. The effect of chitosan thin layer and chitosan-λ-carrageenan bilayer on the drug release was studied at pH values simulating these characteristic for stomach (pH = 1.2) and intestine (pH = 7.4). Chitosan layer slightly increased 5-ASA release at pH = 1.2, whereas double-layer external coating decreased the release rates. Due to the bilayer properties, the micro-carriers were additionally protected against acidic conditions of the stomach and drug release in the intestine could be better controlled. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01700839
- Volume :
- 66
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Polymer Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 57407266
- Full Text :
- https://doi.org/10.1007/s00289-010-0370-2