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Are Lipid Ratios Less Susceptible to Change With Systemic Inflammation Than Individual Lipid Components in Patients With Rheumatoid Arthritis?
- Source :
-
Angiology . 2/1/2011, Vol. 62 Issue 2, p167-175. 9p. - Publication Year :
- 2011
-
Abstract
- Rheumatoid arthritis (RA) associates with excess cardiovascular risk and there is a need to assess that risk. However, individual lipid levels may be influenced by disease activity and drug use, whereas lipid ratios may be more robust. A cross-sectional cohort of 400 consecutive patients was used to establish factors that influenced individual lipid levels and lipid ratios in RA, using multiple regression models. A further longitudinal cohort of 550 patients with RA was used to confirm these findings, using generalized estimating equations. Cross-sectionally, higher C-reactive protein (CRP) levels correlated with lower levels of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol ([HDL-C] P ≤ .015), whereas lipid ratios did not correlate with CRP. The findings were broadly replicated in the longitudinal data. In summary, the effects of inflammation on individual lipid levels may underestimate lipid-associated cardiovascular disease (CVD) risk in RA, thus lipid ratios may be more appropriate for CVD risk stratification in RA. [ABSTRACT FROM PUBLISHER]
- Subjects :
- *STATINS (Cardiovascular agents)
*ANALYSIS of variance
*CARDIOVASCULAR diseases risk factors
*COMPUTER software
*CONFIDENCE intervals
*STATISTICAL correlation
*EPIDEMIOLOGY
*HYPERLIPIDEMIA
*INFLAMMATION
*LIPIDS
*LONGITUDINAL method
*MULTIVARIATE analysis
*REGRESSION analysis
*RESEARCH funding
*RHEUMATOID arthritis
*STATISTICS
*LOGISTIC regression analysis
*DATA analysis
*MULTIPLE regression analysis
*CROSS-sectional method
*RETROSPECTIVE studies
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 62
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 57331360
- Full Text :
- https://doi.org/10.1177/0003319710373749