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Electrochemical synthesis of the new substituted phenylpiperazines
- Source :
-
Journal of Electroanalytical Chemistry . Jan2011, Vol. 651 Issue 1, p72-79. 8p. - Publication Year :
- 2011
-
Abstract
- Abstract: Electrochemical oxidation of 1-(4-(4-hydroxyphenyl)piperazin-1-yl)ethanone (1) has been studied in the presence of arylsulfinic acids (3a–c) as nucleophiles in aqueous solutions using cyclic voltammetry and controlled-potential coulometry methods. The results revealed that quinone-imine derived from oxidation of 1 participates in Michael type addition reaction with 3a–c and via an EC mechanism converts to the corresponding new phenylpiperazine derivatives. The present work has led to the development of a facile and environmentally friendly reagent-less electrochemical method for synthesis of some new phenylpiperazine derivatives in aqueous solutions with high atom economy and safe waste under ambient conditions and in an undivided cell using a carbon electrode. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15726657
- Volume :
- 651
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Electroanalytical Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 57080382
- Full Text :
- https://doi.org/10.1016/j.jelechem.2010.10.024