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Pd-NHC Catalyzed Biaryl Coupling by Direct C-H Activation-A Novel Strategy for the Synthesis of Dibenzocyclooctane Lignans.

Pd-NHC Catalyzed Biaryl Coupling by Direct C-H Activation-A Novel Strategy for the Synthesis of Dibenzocyclooctane Lignans.

Authors :
Coy, EricssonDavid
Cuca, LuisEnrique
Sefkow, Michael
Source :
Synthetic Communications. 2011, Vol. 41 Issue 1, p41-51. 11p.
Publication Year :
2011

Abstract

Cross-coupling reactions, such as Buchwald-Hartwig arylamination and direct intramolecular biaryl coupling by C-H activation, were carried out using various Palladium-N-heterocyclic carbenes (Pd-NHC) as catalysts. The yields were good to excellent. The latter strategy was adopted to transform two dibenzylbutane lignans, isolated from the leaves of Ocotea macrophylla (Lauraceae), into the corresponding dibenzocyclooctane lignans in good overall yields. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00397911
Volume :
41
Issue :
1
Database :
Academic Search Index
Journal :
Synthetic Communications
Publication Type :
Academic Journal
Accession number :
56043219
Full Text :
https://doi.org/10.1080/00397910903531755