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Plasmapheresis-induced remission in otherwise therapy-resistant FSGS.

Authors :
Vécsei, Andreas K. W.
Müller, Thomas
Schratzberger, Edith C.
Kircher, Karl
Regele, Heinz
Arbeiter, Klaus
Schroth, Brigitte
Aufricht, C.
Source :
Pediatric Nephrology. Nov2001, Vol. 16 Issue 11, p898. 3p.
Publication Year :
2001

Abstract

We report an 8-year-old Caucasian boy who presented with steroid-resistant nephrotic syndrome. Renal biopsy showed the cellular variant of focal segmental glomerulosclerosis (FSGS). Within 1 year he received a series of therapies that have induced remission in other patients with this disease, all to no avail (conventional-dose cyclosporin A, methylprednisolone pulse therapy, high-dose cyclosporin A, and therapy with mycophenolate mofetil). He achieved remission after five sessions of plasma exchange. This case argues for aggressive therapy of resistant nephrotic syndrome in the native kidney. Plasma exchange should be considered as a possible rescue therapy arm in future study protocols. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0931041X
Volume :
16
Issue :
11
Database :
Academic Search Index
Journal :
Pediatric Nephrology
Publication Type :
Academic Journal
Accession number :
5592601