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Bayesian analysis for genetic architecture of dynamic traits.
- Source :
-
Heredity . Jan2011, Vol. 106 Issue 1, p124-133. 10p. 4 Charts, 4 Graphs. - Publication Year :
- 2011
-
Abstract
- The dissection of the genetic architecture of quantitative traits, including the number and locations of quantitative trait loci (QTL) and their main and epistatic effects, has been an important topic in current QTL mapping. We extend the Bayesian model selection framework for mapping multiple epistatic QTL affecting continuous traits to dynamic traits in experimental crosses. The extension inherits the efficiency of Bayesian model selection and the flexibility of the Legendre polynomial model fitting to the change in genetic and environmental effects with time. We illustrate the proposed method by simultaneously detecting the main and epistatic QTLs for the growth of leaf age in a doubled-haploid population of rice. The behavior and performance of the method are also shown by computer simulation experiments. The results show that our method can more quickly identify interacting QTLs for dynamic traits in the models with many numbers of genetic effects, enhancing our understanding of genetic architecture for dynamic traits. Our proposed method can be treated as a general form of mapping QTL for continuous quantitative traits, being easier to extend to multiple traits and to a single trait with repeat records. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BAYESIAN analysis
*HAPLOIDY
*GENETIC models
*GENE mapping
*RICE
Subjects
Details
- Language :
- English
- ISSN :
- 0018067X
- Volume :
- 106
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Heredity
- Publication Type :
- Academic Journal
- Accession number :
- 55819065
- Full Text :
- https://doi.org/10.1038/hdy.2010.20