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Is Homatropine 5% effective in reducing pain associated with corneal abrasion when compared with placebo? A randomized controlled trial.
- Source :
-
Emergency Medicine Australasia . Dec2010, Vol. 22 Issue 6, p507-513. 7p. 3 Charts, 1 Graph. - Publication Year :
- 2010
-
Abstract
- To compare the change in visual analogue scale (VAS) pain ratings over 24 h following mechanical corneal abrasion between patients receiving sixth hourly drops of either 5% homatropine or placebo. A triple blind randomized controlled trial was conducted on a convenience sample of eligible consenting adults who were randomized to receive either sixth hourly 5% homatropine (active) or 0.5% hypromellose (placebo) eye drops. VAS pain ratings were performed at 0, 6, 12, 18 and 24 h whereas the study drug was instilled at 0, 6, 12 and 18 h. The primary outcome was attainment of a clinically significant reduction in pain on the VAS (>20 mm decrease) from enrolment to each time point. There were no significant differences in baseline variables or VAS pain ratings at any time point between those in the homatropine ( n= 20) and placebo ( n= 20) groups. The percentages of patients reporting a >20 mm VAS decrease at 12 h were 50% (95% CI -27.2-72.8) and 60% (95% CI -36.1-80.9) for the homatropine and placebo groups, respectively. We found no significant difference in pain score reductions between the two groups but some level of therapeutic benefit is not excluded. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CORNEA injuries
*PARASYMPATHOLYTIC agents
*OPHTHALMIC drugs
*ANALYSIS of variance
*COMPUTER software
*CONFIDENCE intervals
*EMERGENCY medical services
*FISHER exact test
*HEALTH outcome assessment
*PAIN
*PATIENTS
*STATISTICAL sampling
*STATISTICAL hypothesis testing
*U-statistics
*DATA analysis
*PAIN measurement
*RANDOMIZED controlled trials
*TREATMENT effectiveness
*BLIND experiment
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 17426731
- Volume :
- 22
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Emergency Medicine Australasia
- Publication Type :
- Academic Journal
- Accession number :
- 55677054
- Full Text :
- https://doi.org/10.1111/j.1742-6723.2010.01346.x