Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues

Authors :: Zhao, Yu
Zhang, Hong-Bin
Liu, Ji-Kai
Su, Jia
Li, Yan
Yao, Zhu-Jun
Zhao, Qin-Shi
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Jan2011, Vol. 52 Issue 1, p139-142. 4p.
Publication Year :: 2011
Abstract: Abstract: Two interesting unprecedented fragmentations of 13-oxo-taxyunnansin A (3), initiated by treatment with t BuOK and Red-Al, respectively, have been discovered, optimized and successfully applied to the synthesis of novel abeo-paclitaxel and abeo-docetaxel derivatives. Eight new derivatives of abeo-paclitaxel and abeo-docetaxel possessing the structurally simplified 11 (15→1)-abeo-taxane skeleton with an oxetane ring and π bond conjugate system were accordingly prepared for the further evaluation of anticancer activities. [ABSTRACT FROM AUTHOR]

Subjects :: *FRAGMENTATION reactions
*PACLITAXEL
*MOLECULAR structure
*ORGANIC synthesis
*RING formation (Chemistry)
*ANTINEOPLASTIC agents
*CHEMICAL bonds
*BIOCONJUGATES

Language :: English
ISSN :: 00404039
Volume :: 52
Issue :: 1
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 55632121
Full Text :: https://doi.org/10.1016/j.tetlet.2010.11.008

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