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Proline catalyzed direct diastereoselective 6-enolexo aldolization: toward the synthesis of the imino sugar DNJ
- Source :
-
Tetrahedron: Asymmetry . Nov2010, Vol. 21 Issue 21/22, p2703-2708. 6p. - Publication Year :
- 2010
-
Abstract
- Abstract: A l-proline catalyzed direct diastereoselective 6-enolexo aldolization reaction of differentiating dialdehydes derived from tartaric acid is presented. This organocatalytic approach provides high levels of syn-selectivity (dr >10:1) with the stereocontrolled C–C bond formation between C4 and C5 intramolecularly, which can serve to synthesize imino-sugar skeleton quickly. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09574166
- Volume :
- 21
- Issue :
- 21/22
- Database :
- Academic Search Index
- Journal :
- Tetrahedron: Asymmetry
- Publication Type :
- Academic Journal
- Accession number :
- 55623007
- Full Text :
- https://doi.org/10.1016/j.tetasy.2010.10.024