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No alterations of brain GABA after 6months of treatment with atypical antipsychotic drugs in early-stage first-episode schizophrenia
- Source :
-
Progress in Neuro-Psychopharmacology & Biological Psychiatry . Dec2010, Vol. 34 Issue 8, p1480-1483. 4p. - Publication Year :
- 2010
-
Abstract
- Abstract: We investigated the effects of atypical antipsychotic drugs on GABA concentrations in early-stage, first-episode schizophrenia patients. Sixteen (8 males, 8 females; age, 30±11years old) patients were followed up for six months. We also included 18 sex- and age-matched healthy control subjects. All patients were treated with atypical antipsychotic drugs (5 patients with risperidone, 5 patients with olanzapine, 4 patients with aripiprazole, and 2 patients with quetiapine). In all three regions measured (frontal lobe, left basal ganglia, and parieto-occipital lobe), no differences in GABA concentrations were observed in a comparison of pre-treatment levels and those six months after treatment. These results suggest that relatively short-term treatment with atypical antipsychotic drugs may not affect GABAergic neurotransmission; however, it is also possible that such treatment prevents further reductions in brain GABA levels in people with early-stage, first-episode schizophrenia. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02785846
- Volume :
- 34
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Progress in Neuro-Psychopharmacology & Biological Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 55502285
- Full Text :
- https://doi.org/10.1016/j.pnpbp.2010.08.007