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The Aurora-A/TPX2 complex: A novel oncogenic holoenzyme?
- Source :
-
BBA - Reviews on Cancer . Dec2010, Vol. 1806 Issue 2, p230-239. 10p. - Publication Year :
- 2010
-
Abstract
- Abstract: The Aurora-A kinase regulates cell division by phosphorylating multiple downstream targets in the mitotic apparatus. Aurora-A is frequently overexpressed in tumor cells and it is therefore regarded as a novel candidate target in anti-cancer therapy. Its actual contribution to cell transformation, however, is not entirely clarified; furthermore, its transforming ability has been found to vary broadly depending on the systems and experimental conditions in which it was assayed. This variability suggests that Aurora-A overexpression requires the concomitant deregulation of partner factor(s) to fully elicit its oncogenic potential. Molecular and structural studies indicate that the full activation and correct mitotic localisation of Aurora-A require its interaction with the spindle regulator TPX2. In this review we propose a brief reappraisal of Aurora-A intrinsic oncogenic features. We then present literature screening data indicating that TPX2 is also overexpressed in many tumor types, and, furthermore, that Aurora-A and TPX2 are frequently co-overexpressed. We therefore propose that the association of Aurora-A and TPX2 gives rise to a novel functional unit with oncogenic properties. We also suggest that some of the roles that are conventionally attributed to Aurora-A in cell transformation and tumorigenesis could in fact be a consequence of the oncogenic activation of this unit. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0304419X
- Volume :
- 1806
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- BBA - Reviews on Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 55499709
- Full Text :
- https://doi.org/10.1016/j.bbcan.2010.08.001