IS N-ACETYLCYSTEINE USEFUL IN PREVENTION OF CONTRAST INDUCED NEPHROPATHY?

The article discusses a study which analyzes the studies on the potential of N-acetylcysteine (NAC) to reduce the risk of contrast induced nephropathy (CIN) among coronary angiography (CAG) and primary cardiac intervention (PCI) patients. It says that the study used MEDLINE research engine and reviewed various studies including one by Tepel and colleagues, one by Carbonell and associates, and one by Kinbara and partners. Results of the study showed that the outcomes of several researches were conflicting and that others were not able to show CIN decline over hydration. It adds that a comparative trial between NAC and saline hydration showed the latter to be more effective. It concludes that CIN prevention through NAC still requires trials which will assess NAC effect on related results.