Treatment of IgA nephropathy using novel therapeutic strategy: Inflamed site specific gene delivery.

Examines the treatment of IgA nephropathy using novel therapeutic strategy. Preventing nephropathy through local delivery of anti-inflammatory cytokine into glomeruli; Site-specific gene delivery into inflamed glomeruli using a bone marrow-derived cells as vehicle which possesses the ligand of adhesion molecules; Feasibility of the site-specific gene system as therapy for experimental glomerunephritis; Several problems to address before making major investments for clinical use of the site-specific gene system for nephropathy.