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Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?
- Source :
-
European Journal of Applied Physiology . Dec2010, Vol. 110 Issue 6, p1099-1106. 8p. - Publication Year :
- 2010
-
Abstract
- We investigated the association of the angiotensin converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism, alone or in combination with the α-actinin-3 gene (ACTN3) R577X polymorphism, with jumping (vertical squat and counter-movement jump tests) and sprint ability (30 m dash) in non-athletic, healthy young adults [N = 281 (214 male), mean (SD) age 21 (2) years]. We did not observe any effect of the ACE I/D polymorphism on study phenotypes. We repeated the analyses separately in men and women and the results did not materially change. Likewise, the mean estimates of the study phenotypes were similar in subjects with the genotype combinations ACE II + ID and ACTN3 XX or ACE DD and ACTN3 RR + RX. We found no association between the ACE DD and ACTN3 RR + RX genotype combination and performance (≥90th of the sex-specific percentile). In summary, though the ACE I/D polymorphism is a strong candidate to modulate some exercise-related phenotypes or athletic performance status, this polymorphism, alone or in combination with the ACTN3 R577X polymorphism, does not seem to exert a major influence in the muscle 'explosive' power of young healthy adults, as assessed during multi-joint exercise tests. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MUSCLE strength
*GENETIC polymorphisms
*PHENOTYPES
*GENOTYPE-environment interaction
*ANGIOTENSIN converting enzyme
*ACTIN
*PROTEIN genetics
*SPRINTING
*JUMPING
*COMBINATORICS
*HEALTH of young adults
*SKELETAL muscle physiology
*AMINO acids
*ARGININE
*ATHLETES
*ATHLETIC ability
*CLINICAL trials
*COMPARATIVE studies
*EXERCISE tests
*RESEARCH methodology
*MEDICAL cooperation
*MUSCLE proteins
*GENETIC mutation
*RESEARCH
*EVALUATION research
*SKELETAL muscle
Subjects
Details
- Language :
- English
- ISSN :
- 14396319
- Volume :
- 110
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- European Journal of Applied Physiology
- Publication Type :
- Academic Journal
- Accession number :
- 55266804
- Full Text :
- https://doi.org/10.1007/s00421-010-1608-2