Anti-infective external coating of central venous catheters: A randomized, noninferiority trial comparing 5-fluorouracil with chlorhexidine/silver sulfadiazine in preventing catheter colonization.

The article presents the results of a study which compared the effectiveness and safety of anti-infective coating materials 5-fluorouracil and chlorhexidine/silver sulfadiazine in preventing colonization in central venous catheters. According to the authors, 5-fluorouracil was more efficient in controlling incidence of catheter colonization than chlorhexidine and silver sulfadiazine. They add that catheter-related bloodstream infection did not occur when 5-fluorouracil was used while two episodes occurred using chlorhexidine/silver sulfadizine group.