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Isolation and characterization of cytotoxic compounds from Euphorbia cornigera Boiss.
- Source :
-
Journal of Asian Natural Products Research . Nov2010, Vol. 12 Issue 11, p985-991. 7p. 2 Diagrams, 3 Charts. - Publication Year :
- 2010
-
Abstract
- Methanolic extract of Euphorbia cornigera shoots was separated using HPLC, affording compounds 1-4. Their structures and relative stereochemistry were established after obtaining their spectroscopic (IR, 1H, 13C NMR COSY-45°, HOHAHA, HSQC, HMBC, NOESY, and mass measurement) data. On the basis of these data, the compounds were characterized as 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-O-tetradecanoylingenol (1), 3-O-decanoyl-20-O-hexanoylingenol (2), 3-O-(2,3-dimethylbutanoyl)-13-O-dodecanoyl-20-O-hexadecanoylingenol (3), and 13-O-dodecanoyl-20-O-hexanoylingenol (4); among these compounds, two (1 and 2) were new metabolites while the rest (3 and 4) were known. The MTT cytotoxicity assay was carried out using amrubicin hydrochloride as a positive control. Compound 1 displayed IC50 as 5.0 and 2.9 μM against RAW and HT-29 cell lines, respectively, which is 5- and 1.5-folds stronger than the control with IC50 values of 25 and 4.36 μM, respectively. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 12
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 55116137
- Full Text :
- https://doi.org/10.1080/10286020.2010.512007