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Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts: a coordinated study of 1,797 European and US men
- Source :
-
Fertility & Sterility . Nov2010, Vol. 94 Issue 6, p2128-2134. 7p. - Publication Year :
- 2010
-
Abstract
- <bold>Objective: </bold>To describe associations between serum inhibin-b and sperm counts, adjusted for effect of time of blood sampling, in larger cohorts than have been previously reported.<bold>Design: </bold>Cross-sectional studies of spermatogenesis markers.<bold>Setting: </bold>Four European and four US centers.<bold>Patient(s): </bold>Fertile men (1,797) were included and examined from October 1996-February 2005.<bold>Intervention(s): </bold>The study was observational and therefore without any intervention.<bold>Main Outcome Measure(s): </bold>Associations between inhibin-b and semen variables controlled for time of blood sampling and other covariates.<bold>Result(s): </bold>Inhibin-b decreased about 2.00% per hour from 8 am-12 pm and then about 3.25% per hour from 12 pm-4 pm. There was a strong positive association between inhibin-b levels less than 150 pg/mL and both sperm concentration and total sperm count (slopes of the regression lines were β=0.011 and β=0.013 for natural logarithm-transformed sperm concentration and total sperm count, respectively). For inhibin-b levels of 150-300 pg/mL the associations were not as steep (β=0.002), but still significant. For inhibin-b levels more than 300 pg/mL there was little association to the sperm counts. Neither sperm motility nor morphology was significantly related to inhibin-b level in any group.<bold>Conclusion(s): </bold>Serum inhibin-b levels decrease nonlinearly during the daytime, and are positively correlated with sperm counts, but the predictive power is best when inhibin-b is low. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00150282
- Volume :
- 94
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Fertility & Sterility
- Publication Type :
- Academic Journal
- Accession number :
- 54653192
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2009.12.051