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Pathogenic role of immune response to M3 muscarinic acetylcholine receptor in Sjögren’s syndrome-like sialoadenitis
- Source :
-
Journal of Autoimmunity . Dec2010, Vol. 35 Issue 4, p383-389. 7p. - Publication Year :
- 2010
-
Abstract
- Abstract: The aim of this study was to clarify the role of the immune response to muscarinic type 3 receptor (M3R) in the pathogenesis of Sjögren’s syndrome (SS). M3R−/− mice were immunized with murine M3R peptides and their splenocytes were inoculated into Rag1−/− (M3R−/−→Rag1−/−) mice. M3R−/−→Rag1−/− mice had high serum levels of anti-M3R antibodies and low saliva volume. Histological examination showed marked infiltration of mononuclear cells in the salivary glands and immunohistochemistry demonstrated that the majority of these cells were CD4+ T cells with a few B cells and several IFN-γ- and IL-17-producing cells. Apoptotic cells were present in the salivary glands of M3R−/−→Rag1−/− mice. Moreover, transfer of only CD3+ T cells from M3R−/− immunized with M3R peptides into Rag1−/− mice resulted in cell infiltration and destruction of epithelial cells in the salivary glands, suggesting that M3R reactive CD3+ T cells play a pathogenic role in the development of autoimmune sialoadenitis. Our findings support the notion that the immune response to M3R plays a crucial role in the pathogenesis of SS-like autoimmune sialoadenitis. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 08968411
- Volume :
- 35
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Autoimmunity
- Publication Type :
- Academic Journal
- Accession number :
- 54650390
- Full Text :
- https://doi.org/10.1016/j.jaut.2010.08.004