NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL Correspondence.

The article offers information on the advancement in the process of diagnosis, prognosis, and treatment of B-cell chronic lymphocytic leukaemia (B-CLL). It mentions that high expression of zeta-chain-associated protein kinase 70 (ZAP-70) and unmutated immunoglobulin heavy variable (IGHV) genes are considered poor factors for prognosis. It informs that NOTCH1 and PEST mutations are considered as marker of poor prognosis in a minority of B-CLL patients.