P16 Dual nucleoside therapy in the era of HAART.

Background: Individuals with HIV/AIDS generally experience decreased levels of health-related quality-of-life (HR-QoL). However, very few HR-QoL data exist for these individuais following the introduction of HAART. Methods: Individuals with HIV/AIDS were asked to complete the Medical Outcomes Study-HIV questionnaire, which measures HRQoL on 11 separate profiles from 0 to 100. Regression analysis was used to see whether CD4 count (cells/mm[sup 3] and logged vital load (copies/mL) predicted these scores once they had been factorized. Results: The 73 individuals who responded had a mean age of 37.4 (SD 8.1). The median CD4 count and logged vital load was 369 (range 0-1044) and 3.04 (range 1.69-5.82). The mean HR-QoL scores ranged between 49.4 and 70.3 but CD4 count did not predict HR-QoL (P=0.82). However, logged vital load independently predicted HR-QoL (P=0.02) after adjusting for differences in gender, mode of HIV transmission and age. Conclusion: Individuals with HIV/AIDS are still experiencing decreased levels of HR-QoL. Information on vital load may be more useful than CD4 counts in predicting HR-QoL in the era of HAAT. Background: Individuals with HIV/AIDS generally experience decreased levels of health-related quality-of-life (HR-QoL). However, very few HR-QoL data exist for these individuais following the introduction of HAART. Methods: Individuals with HIV/AIDS were asked to complete the Medical Outcomes Study-HIV questionnaire, which measures HRQoL on 11 separate profiles from 0 to 100. Regression analysis was used to see whether CD4 count (cells/mm[sup 3] and logged vital load (copies/mL) predicted these scores once they had been factorized. Results: The 73 individuals who responded had a mean age of 37.4 (SD 8.1). The median CD4 count and logged vital load was 369 (range 0-1044) and 3.04 (range 1.69-5.82). The mean HR-QoL scores ranged between 49.4 and 70.3 but CD4 count did not predict HR-QoL (P=0.82). However, logged vital load independently... [ABSTRACT FROM AUTHOR]