Back to Search
Start Over
Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: Definitions, frequency and pharmacological aspects
- Source :
-
Journal of Crohn's & Colitis . Oct2010, Vol. 4 Issue 4, p355-366. 12p. - Publication Year :
- 2010
-
Abstract
- Abstract: The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 18739946
- Volume :
- 4
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Crohn's & Colitis
- Publication Type :
- Academic Journal
- Accession number :
- 54227516
- Full Text :
- https://doi.org/10.1016/j.crohns.2010.04.004