Back to Search
Start Over
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Oct2010, Vol. 20 Issue 20, p6034-6039. 6p. - Publication Year :
- 2010
-
Abstract
- Abstract: The structure–activity relationship of the prime region of hydroxyethylamine BACE inhibitors is described. Variation in the aryl linker region with 5- and 6-membered heterocycles provided compounds such as 33 with improved permeability and reduced P-gp liability compared to benzyl amine analog 1. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 20
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 53789732
- Full Text :
- https://doi.org/10.1016/j.bmcl.2010.08.070