New neo-clerodane diterpenoids from Scutellaria barbata with cytotoxic activities

Authors :: Dai, Sheng-Jun
Qu, Gui-Wu
Yu, Qun-Ying
Zhang, De-Wu
Li, Gui-Sheng
Source :: Fitoterapia. Oct2010, Vol. 81 Issue 7, p737-741. 5p.
Publication Year :: 2010
Abstract: Two new neo-clerodane diterpenoids have been isolated from the whole plant of Scutellaria barbata D. Don, and their structures were established by detailed spectral analyses as scutehenanine H (1) and 6-(2,3-epoxy-2-isopropyl-n-propoxyl)barbatin C (2). In vitro, the isolated two new compounds showed significant cytotoxic activities against three human cancer lines, and gave IC50 values in the range OF 2.0-4.2μΜ. [Copyright &y& Elsevier]

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