99mTc-labeled-1-thio-β-d-glucose as a new tool to temporomandibular joint inflammatory disorders diagnosis

Abstract: Aim: The aim of this study was to evaluate early detection of temporomandibular joint (TMJ) inflammatory changes based on 1-thio-β-d-glucose radiolabeled with technetium-99m. Method: The method applied a TMJ inflammation model in rats followed by radiopharmaceutical synthesis, intravenous administration of 99mTc-1-TG and kinetic scintigraphy imaging. Results: Results show a significant difference of 99mTc-1-TG uptake between inflamed TMJ and the control joint. The biodistribution of 99mTc-1-TG by images showed the kidneys’ excretion. Conclusion: As conclusion, 99mTc-1-TG is a helpful tool in TMJ inflammatory process detection. [Copyright &y& Elsevier]