Cognitive Inflexibilily and Frontal-Cortical Activation in Pediatric Obsessive- Compulsive Disorder.

The article discusses a study on deficits in cognitive flexibility and frontal-cortical activation in obsessive-compulsive disoder (OCD) in children. It states that cognitive flexibility and response inhibition are linked to perturbations in cortico-striatal-thalamic circuitry. The study uses a functional magnetic resonance imaging (fMRI) in subjects aged 10-17 years under OCD and healthy comparison groups. The study reveals that those in the OCD group are slower to respond than the HC group.