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Correlation between glucose fluctuations and carotid intima-media thickness in type 2 diabetes
- Source :
-
Diabetes Research & Clinical Practice . Oct2010, Vol. 90 Issue 1, p95-99. 5p. - Publication Year :
- 2010
-
Abstract
- Abstract: Aims: To evaluate the relationship between blood glucose fluctuations and carotid atherosclerosis (AS) in type 2 diabetic patients. Methods: A case-control study included 36 patients with type 2 diabetes and 10 controls. According to the levels of carotid intima-media thickness (CIMT), 36 diabetic patients were classified into two groups, the diabetes mellitus without atherosclerosis (DM−AS, n =20) and diabetes mellitus with atherosclerosis (DM+AS, n =16). The glucose excursions were assessed by the following parameters obtained from continuous glucose monitoring system for 72h: the mean blood glucose (MBG) and its standard deviation (SD), the area under the ROC curve when the blood glucose was higher than 7.8mmol/L (AUC7.8), the mean amplitude of glycemic excursion (MAGE), the mean of daily differences (MODD), and the largest amplitude of glycemic excursion (LAGE). Results: The levels of MBG, SD, MAGE, LAGE, and AUC7.8 were gradually increased with the progression of atherosclerosis (P <0.05). The Spearman''s correlation analysis showed that the CIMT was correlated to the age (R =0.58, P <0.001), the duration (R =0.50, P <0.001), the MAGE (R =0.34, P =0.021), and the LAGE (R =0.31, P =0.035). Conclusion: These results suggest that glucose fluctuations may accelerate atherogenesis in older type 2 diabetic patients who had a longer duration. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01688227
- Volume :
- 90
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Diabetes Research & Clinical Practice
- Publication Type :
- Academic Journal
- Accession number :
- 53418120
- Full Text :
- https://doi.org/10.1016/j.diabres.2010.05.004