Magnesium dependent complexation of tri-anionic calix[4]arene detergents by the nucleotide binding domain 1 (NBD1) of multidrug resistance protein MRP1.

Authors :: Nault, Laurent F. A.
Girardot, Celine
Leydier, Antoine
Coleman, Anthony W.
Perrotton, Thomas
Magnard, Sandrine
Baubichon-Cortay, Helene
Source :: New Journal of Chemistry. Sep2010, Vol. 34 Issue 9, p1812-1815. 4p.
Publication Year :: 2010
Abstract: The tri-carboxylatomethylene-mono-alkoxy calix[4]arenes have been shown by fluorescence spectroscopy to bind to the NBD1 domain of MRP1 protein in a magnesium dependent manner. The observed associations constants are of the same order as that observed for ATP–Mg, the natural substrate for this protein. [ABSTRACT FROM AUTHOR]

Subjects :: *MAGNESIUM
*CALIXARENES
*DETERGENTS
*NUCLEOTIDES
*FLUORESCENCE spectroscopy
*PROTEINS

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