Squalamine, an original chemosensitizer to combat antibiotic-resistant Gram-negative bacteria.

The article discusses the results of a study on the use of squalamine as a chemosensitizer to prevent antibiotic-resistant gram-negative bacteria. According to the authors, the effect of squalamine on bacterial strains devoid of porin showed an increase in penetration for cefepime and ciprofloxacin. They add that squalamine allows an increase in bacterial susceptibility when the mechanical barrier, restricted uptake or efficient efflux pump are involved in resistance.