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Association between anti-β2 glycoprotein I antibodies and renal glomerular C4d deposition in lupus nephritis patients with glomerular microthrombosis: a prospective study of 155 cases.
- Source :
-
Lupus . Sep2010, Vol. 19 Issue 10, p1195-1203. 9p. 8 Color Photographs, 4 Charts, 2 Graphs. - Publication Year :
- 2010
-
Abstract
- Glomerular microthrombosis (GMT) is a common vascular change in patients with lupus nephritis (LN). The mechanism underlying GMT is still unknown. In our previous study, we found that the level of IgG anti-β2 glycoprotein I (β2GPI) antibodies was higher in the LN-GMT group than in the LN-non-GMT group, which indicated that anti-β2GPI antibodies may play a role in GMT formation. Many studies have demonstrated that the activation of the classical complement pathway may play a critical role in fetal loss and aPL-induced thrombosis formation. To investigate whether complement activation plays a role in GMT formation and to evaluate its relationship with aPL, we prospectively investigated deposition of C4d in 155 renal biopsy specimens of LN patients. The results revealed a strong relationship between the intensity of glomerular C4d staining and the presence of microthrombi (p<0.001). The detection rate of IgG anti-b2GPI antibodies was higher in the LN-GMT group than in the LN-non-GMT group (p<0.05). Further, the intensity of glomerular C4d staining was significantly related with IgG anti-β2GPI antibodies (p<0.05). The results of our study suggest that anti-β2GPI antibodies may play a role in GMT formation, and this process might involve complement activation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LUPUS nephritis
*GLYCOPROTEINS
*KIDNEY glomerulus
*THROMBOSIS
*IMMUNOGLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 09612033
- Volume :
- 19
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Lupus
- Publication Type :
- Academic Journal
- Accession number :
- 53270771
- Full Text :
- https://doi.org/10.1177/0961203310368409