Effects of augmented delivery of pyruvate on myocardial high energy phosphate metabolism at high workstate.

Examines the cause of the fall in myocardial high-energy phosphates that occurs during high cardiac workstates. Influence of supplemental pyruvate and butyrate on reductions in myocardial phosphocreatine (PCr)/adenosine triphosphate (ATP); Implications of the PCr/ATP fall during catecholamine infusion; Process influenced by pyruvate infusion; Alternative mechanisms for pyruvate effects on PCr/ATP.