FOOD DEXTRIN PROTECTS AGAINST COLONIC INFLAMMATION AND PREVENTS COGNITIVE IMPAIRMENTS.

The aim of the present study was to investigate the protective effects of the dextrin NUTRIOSE®6 (Dex) on colonic inflammation. Five percent of Dex or Glucose (Glu) diets were administered for 2 weeks to Wistar male rats prior to colitis induction with 1mg of TNBS (2,4,6-Trinitrobenzenesulfonic acid) or 20% ethanol (vehicle). An aversive light stimulus avoidance test (ALSAT) was performed to assess the cognitive performances of rats that are correlated to pain. Growth, food intake and biological parameters as caecal wall thickness, enzyme activities, short chain fatty acid content were investigated. Macro and microscopic scores of colonic inflammation of each treatment groups were compared. The results suggest that Dex prevents colonic inflammation induced by ethanol and TNBS administrations and have positive consequences on cognitive impairments. [ABSTRACT FROM AUTHOR]