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Long-term remission of nephrotic syndrome with etanercept for concomitant juvenile idiopathic arthritis.
- Source :
-
Pediatric Nephrology . Oct2010, Vol. 25 Issue 10, p2175-2177. 3p. 1 Graph. - Publication Year :
- 2010
-
Abstract
- Etanercept is a tumor necrosis factor (TNF)-α inhibitor that has been applied beneficially for juvenile idiopathic arthritis (JIA). We experienced long-term remission of nephrotic syndrome (NS) in a boy treated with etanercept, which was initially used for concomitant JIA. He developed NS at age 3 years 7 months and had mostly been treated with cyclosporine because of steroid dependency and frequent relapses. Cyclosporine was halted at 10 years 7 months because of nephrotoxicity, and he was subsequently treated with mizoribine. However, he had three relapses in the first year and developed JIA at 11 years 7 months. He was treated with sulfasalazine, methotrexate, and prednisolone, but his arthritis persisted. Etanercept was started at 12 years 3 months. Thereafter, his arthritis went into complete remission. Surprisingly, he has remained relapse-free for both NS and JIA for more than 3 years with etanercept and mizoribine. It is difficult to know whether the NS remission after initiating etanercept was coincidental. However, there are many reports of increased TNF-α or soluble TNF-α receptor in NS relapse. To date, there are two reports of the efficacy of TNF-α inhibitors against NS. It is possible that TNF-α inhibitors may have potential as therapeutic agents for NS. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ETANERCEPT
*ADRENOCORTICAL hormones
*ANTI-inflammatory agents
*CYCLOSPORINE
*NAPROXEN
*NEPHROTIC syndrome
*HEALTH outcome assessment
*JUVENILE idiopathic arthritis
*TUMOR necrosis factors
*DISEASE relapse
*TREATMENT effectiveness
*DISEASE remission
*CHEMICAL inhibitors
*ETIOLOGY of diseases
*DRUG therapy
*CHILDREN
*THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 0931041X
- Volume :
- 25
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Pediatric Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 52946675
- Full Text :
- https://doi.org/10.1007/s00467-010-1571-5