Association of Interleukin-1 Receptor Antagonist Gene Polymorphism With Response to Conservative Treatment of Lumbar Herniated Nucleus Pulposus.

The article details a study which examined the relationship between gene polymorphism in interleukin 1 receptor antagonist (IL1RN) and the response of lumbar herniated nucleus pulposus (HNP) to conservative treatment. The study included 54 single level subligamentous extruded lumbar HNP patients whose variable number tandem repeat polymorphism of IL1RN genes were compared with 227 healthy adult controls. Study authors concluded that high allele prevalence of A3 influence the clinical progression and response to conservative treatment for lumbar HNP.