On the potential of natural products in the discovery of pharma leads: A case for reassessmentThis paper is part of an NPRthemed issue on Synthesis, guest-edited by Andreas Kirschning and Andy Phillips.

The central proposition advanced herein is that complex target oriented synthesis, enabled by historic advances in methodology, has enormously expanded the scope of the possible. Accordingly, natural products, a proven long-term source of pharma discovery, re-emerge as potentially valuable elements for synthesis-driven pharma exploitation. [ABSTRACT FROM AUTHOR]