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Protease inhibitors atazanavir, lopinavir and ritonavir are potent blockers, but poor substrates, of ABC transporters in a broad panel of ABC transporter-overexpressing cell lines.
- Source :
-
Journal of Antimicrobial Chemotherapy (JAC) . Aug2010, Vol. 65 Issue 8, p1672-1680. 9p. 2 Charts, 3 Graphs. - Publication Year :
- 2010
-
Abstract
- Objectives: A possible mechanism for HIV therapy failure is the efflux of HIV drugs from viral target cells or certain body compartments by ATP-binding cassette (ABC) transporters, allowing ongoing viral replication. Here, we investigated the interaction between protease inhibitors (PIs) and ABC transporters. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 03057453
- Volume :
- 65
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Antimicrobial Chemotherapy (JAC)
- Publication Type :
- Academic Journal
- Accession number :
- 52348289
- Full Text :
- https://doi.org/10.1093/jac/dkq209