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Modification, characterization and structure–anticoagulant activity relationships of persimmon polysaccharides
- Source :
-
Carbohydrate Polymers . Sep2010, Vol. 82 Issue 2, p515-520. 6p. - Publication Year :
- 2010
-
Abstract
- Abstract: Six chemical sulfated polysaccharide derivatives (PFP-S) with variable degree of substitution (DS) and molecular weights (Mw) were prepared from the fresh persimmon fruits by chlorosulfonic acid-pyridine and ultrasonic degradation methods, and the effectiveness of the reaction was monitored by the DS, FT-IR and ζ-potential analysis. The sulfation modification might cause advanced structure change to the samples, the SEM of PFP-S exhibited a polyphasic convoluted structure. Results of anticoagulant activities showed that PFP-S could prolong activated partial thromboplastin time (APTT) and thrombin time (TT), but not prothrombin time (PT), and the anticoagulant activity improved with the increasing DS and decreasing Mw. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01448617
- Volume :
- 82
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Carbohydrate Polymers
- Publication Type :
- Academic Journal
- Accession number :
- 52306085
- Full Text :
- https://doi.org/10.1016/j.carbpol.2010.05.008