Back to Search
Start Over
Synthesis and MDR inhibitory activity evaluation of derivatives of schizandrin A.
- Source :
-
Journal of Asian Natural Products Research . Jul2010, Vol. 12 Issue 7, p549-556. 8p. 1 Diagram, 2 Charts. - Publication Year :
- 2010
-
Abstract
- Eighteen schizandrin A derivatives, possessing an acyl group at 7-OH and/or halogen(s) at C-4 and C-11, were designed and synthesized for evaluation of their in vitro ability to inhibit multidrug resistance (MDR). They exhibit weak ability to restore the intracellular Rhodamine 123 in human hepatocarcinoma MDR cell lines Bel7402 and HCT8 relative to the reference drug verapamil. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIGNANS
*SCHISANDRA
*MULTIDRUG resistance
*VERAPAMIL
*LIVER cancer
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 12
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 52237200
- Full Text :
- https://doi.org/10.1080/10286020.2010.484387