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Depressive and anxiety disorders and risk of subclinical atherosclerosis: Findings from the Netherlands Study of Depression and Anxiety (NESDA)
- Source :
-
Journal of Psychosomatic Research . Aug2010, Vol. 69 Issue 2, p203-210. 8p. - Publication Year :
- 2010
-
Abstract
- Abstract: Objective: Current evidence regarding the association between psychopathology and subclinical atherosclerosis show inconsistent results. The present study examined whether subclinical atherosclerosis was more prevalent in a large cohort of persons with depressive or anxiety disorders as compared to non-depressed and non-anxious controls. Methods: Baseline data from the Netherlands Study of Depression and Anxiety were used, including 2717 persons, free of clinical cardiovascular disease. Participants had a DSM-IV-based current or remitted depressive (major depressive disorder, dysthymia) or anxiety (social phobia, generalized anxiety disorder, panic disorder, agoraphobia) disorder (n=2115) or were healthy controls (n=602). Additional clinical characteristics (severity, duration, age of onset and medication) were assessed. Ankle-brachial index (ABI) was used as a measure of vascular risk and was categorized as low (≤0.90) and mildly low ABI (0.90–1.11) indicating subclinical atherosclerosis, and high ABI (>1.40), which was previously designated as a cardiovascular risk factor, reflecting arterial stiffness and wall calcification. Results: As compared to normal controls, persons with current (i.e., past year) depressive, anxiety or comorbid depressive and anxiety disorders showed a two- to threefold increased odds of low ABI (OR=2.78, 95% CI=1.05–7.35; OR=3.14, 95% CI=1.25–7.85; OR=2.67, 95% CI=1.09–6.51, respectively). No associations were found with mildly low or high ABI. Also, we did not further find a differential role for symptoms severity, duration, age of onset, and use of psychotropic medication in the link between psychopathology and subclinical atherosclerosis. Conclusion: Persons with current depressive or anxiety disorders were more likely to have subclinical atherosclerosis compared to healthy controls. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00223999
- Volume :
- 69
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Psychosomatic Research
- Publication Type :
- Academic Journal
- Accession number :
- 52211039
- Full Text :
- https://doi.org/10.1016/j.jpsychores.2010.01.005