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Bone osteoblastic and mesenchymal stromal cells lack primarily tumoral features in multiple myeloma patients.

Authors :
Giuliani, N.
Lisignoli, G.
Novara, F.
Storti, P.
Zaffaroni, N.
Villa, R.
Sammarelli, G.
Agnelli, L.
Todoerti, K.
Bernardo, M. E.
Manferdini, C.
Colla, S.
Abeltino, M.
Bolzoni, M.
Rocci, A.
Gabusi, E.
Palumbo, A.
Zuffardi, O.
Neri, A.
Rizzoli, V.
Source :
Leukemia (08876924). Jul2010, Vol. 24 Issue 7, p1368-1370. 3p. 1 Chart, 1 Graph.
Publication Year :
2010

Abstract

The article presents a study conducted to examine tumoral features in multiple myeloma patients. It observes that the multiple myeloma patients both bone osteoblastic (OBs) and mesenchymal stromal cells (MSCs) lacks features of tumornal. It also states that transcriptional alterations of MSCs and OBs do not depend on primary karyotype or telomerase alterations in patients with multiple myeloma.

Details

Language :
English
ISSN :
08876924
Volume :
24
Issue :
7
Database :
Academic Search Index
Journal :
Leukemia (08876924)
Publication Type :
Academic Journal
Accession number :
52175231
Full Text :
https://doi.org/10.1038/leu.2010.96