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Regulation of p53 localization.
- Source :
-
European Journal of Biochemistry . May2001, Vol. 268 Issue 10, p2779-2783. 5p. - Publication Year :
- 2001
-
Abstract
- Despite intensive study of p53, the regulation of p53 cellular localization is still poorly understood. This is an overview of the elements and molecules involved in p53 nucleocytoplasmic transportation. These include the nuclear import and export signals of p53, inhibition of p53 nuclear import and export by oligomerization, MDM2-mediated p53 nuclear export, and possible roles of p53 phosphorylation in regulating p53 cellular localization. Finally, questions regarding p53 cellular trafficking will also be discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00142956
- Volume :
- 268
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- European Journal of Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 5208190
- Full Text :
- https://doi.org/10.1046/j.1432-1327.2001.02227.x