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A 3-year Mediterranean-style dietary intervention may modulate the association between adiponectin gene variants and body weight change.
- Source :
-
European Journal of Nutrition . Aug2010, Vol. 49 Issue 5, p311-319. 9p. 5 Charts. - Publication Year :
- 2010
-
Abstract
- Adiponectin gene variations have been associated with obesity. There are few interventional studies analyzing this association. The aim of this study was to analyze the effects of a nutritional intervention with Mediterranean-style diet and three (−4034A/C, +45T/G, and +276 G/T) adiponectin gene variants on 3-year body weight changes in high cardiovascular risk patients. A total of 737 participants, aged 55–80 at high cardiovascular risk were assigned to a low-fat diet or to a Mediterranean-style diet (MD) groups, one with high intake of virgin olive oil (VOO) and the other with high intake of nuts. Anthropometric parameters were taken at baseline and after 3-year follow-up, and the genotyping of the −4034A/C, +45T/G, and +276 G/T polymorphisms was done. GG genotype of the +45T/G polymorphism was associated with 3-year higher body weight gain ( B = 1.399; B = 0.043). TT genotype of the +276G/T polymorphism was linked to the highest 3-year body weight gain in men. Both Mediterranean diets appeared to reverse this effect ( p for interaction = 0.053). Adiponectin gene variation appeared to be associated with 3-year body weight changes in a high cardiovascular risk population. This association may be modulated by a nutritional intervention with a Mediterranean-style diet. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OBESITY
*GENETIC research
*CARDIOVASCULAR system
*GENETIC polymorphisms
*OLIVE oil
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 49
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 52057150
- Full Text :
- https://doi.org/10.1007/s00394-009-0090-2